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Eugene Applebaum College of Pharmacy and Health Sciences

Hanley Abramson, Ph.D.

Hanley Abramson, Ph.D.

Professor Emeritus

Email

hanley@wayne.edu

Department

Pharmaceutical Sciences

Appointments

Professor, Department of Pharmaceutical Sciences

Hanley Abramson, Ph.D.

Degrees and Certifications

B.S. in Pharmacy, Wayne State University, Detroit, MI, 1962
M.S. in Pharmaceutical Chemistry, University of Michigan, Ann Arbor, MI, 1963
Ph.D. in Pharmaceutical Chemistry, University of Michigan, Ann Arbor, MI, 1966 
R.Ph., State of Michigan, 1964

Positions and Employment

  • Professor of Medicinal Chemistry, Wayne State University, College of Pharmacy and Allied Health Professions, 1978-present
  • Associate Professor of Pharmaceutical Chemistry, Wayne State University, College of Pharmacy and Allied Health Professions, 1973-78; Awarded tenure effective July 1, 1973
  • Assistant Professor of Pharmaceutical Chemistry, Wayne State University, College of Pharmacy, 1967-73
  • National Science Foundation Postdoctoral Fellow, The Hebrew University of Jerusalem, Israel, Department of Pharmaceutical Chemistry, 1966-67

Administrative Experience at Wayne State University

  • Interim Deputy Dean of Pharmacy, January 2000-June 2002
  • Associate Dean for Academic Affairs, College of Pharmacy and Allied Health Professions, September 1996-December, 1999
  • Associate Vice President for Academic Affairs, September 1995 to December 1995. On administrative leave, January-August 1996
  • Associate Provost, September 1991-September, 1995
  • Interim Director, Institute of Chemical Toxicology, August 1986 to January 1988
  • Interim Dean, College of Pharmacy and Allied Health Professions, May 1987-July 1988
  • Chair, Department of Pharmaceutical Sciences, College of Pharmacy and Allied Health Professions, April 1987-June 1993
  • Acting Chair, Department of Pharmaceutical Sciences, College of Pharmacy and Allied Health Professions, August 1986-April 1987

Professional Memberships

  • American Chemical Society
  • American Pharmacists Association
  • Michigan Pharmacists Association
  • American Association for the Advancement of Science
  • American Association of Colleges of Pharmacy
  • Wayne State University Pharmacy Alumni Association
  • Christian Pharmacists Fellowship International

Primary Research Interest

Synthesis and biochemical pharmacology of natural products and their analogs

Recent Publications

Research Publications

  1. J.H. Burckhalter and Hanley N. Abramson, "Total Synthesis of 8,13-Diazasteroids," Chemical Communications, 1966, 805.
  2. Hanley N. Abramson, Ph.D. Thesis, University of Michigan , 1966, "Total Synthesis of 8,13-Diazasteroids", Dissertation Abstracts,28, 4957 (1968).
  3. J.H. Burckhalter, Hanley N. Abramson, John G. MacConnell, Ronald J. Thill, Arthur J. Olson, Jonathan C. Hanson, and C.E. Nordman, "Synthesis and X-Ray Structure of the 8,13-Diazasteroid System," Chemical Communications, 1968,1274-1275.
  4. Hanley N. Abramson and Jung-Sook K. Cho, "Inhibition of Sodium- and Potassium-Dependent Adenosine Triphosphatase by Cardenolide Alkylating Agents," Journal of Medicinal Chemistry, 14, 509-511 (1971).
  5. Hanley N. Abramson and Chung Su Kim, "Hydrocarbon and Steroidal Constituents of Gymnocladus dioica," Phytochemistry, 12, 951-952 (1973).
  6. Thomas Tobin and Hanley Abramson, "Irreversible Inhibition of 3H-Ouabain Binding to Na + + K + - ATPase by Digoxigenin-3,-12-Dibromacetate, an Alkylating Derivative of Digoxigenin," European Journal of Pharmacology, 32, 243-250 (1975).
  7. Henry C. Wormser and Hanley N. Abramson, "Synthesis of dl-4- x -(4-Carboxybutyl)-5-carbethoxy-cis hexahydropyrrolo[3,4-d]-imidazol-2-one:N-Carbethoxyazabiotin," Journal of Pharmaceutical Sciences, 64, 1514-1517 (1975).
  8. Henry C. Wormser and Hanley N. Abramson, "Synthesis of dl-4 x -(2-Carboxyethyl)-cis-hexahydropyrrolo[3,4-d]imidazol-2- one: Bisnorazabiotin," Journal of Pharmaceutical Sciences, 64, 1882- 1884 (1975).
  9. Hanley N. Abramson, Chian L. Huang, Thomas F. Wu, and Thomas Tobin, "Thiocardenolides I. Synthesis and Biological Actions of 3 b -thiocyanato-14 b -hydroxy-5 b -card-20(22)-enolide," Journal of Pharmaceutical Sciences, 65, 765-768 (1976).
  10. Henry C. Wormser and Hanley N. Abramson, "Air Oxidation of Tetrasubstituted 3-Pyrrolines to Their Corresponding Pyrroles in the Solid State ," Journal of Heterocyclic Chemistry, 13, 113-116 (1976).
  11. Hanley N. Abramson, Chian L. Huang, Chiu-Chung Ho, Lawrence L. Walny, and You-Meei Hsu, "Thiocardenolides II. Synthesis and Pharmacological Evaluation of 3 b -Thioacetyl-14 b -hydroxy-5 b -card-20(22)-enolide,"Journal of Pharmaceutical Sciences, 66, 602-603 (1977).
  12. Henry C. Wormser and Hanley N. Abramson, "The Total Synthesis ofdl-3a,4.6a-cis-4-(4-Carboxybutyl)-hexahydropyrrolo[3,4-d]imidazol-2-one Hydrochloride (dl-Azabiotin Hydrochloride)", Journal of Pharmaceutical Sciences, 66, 1208-1210 (1977).
  13. Milton D. Glick, Henry C. Wormser, and Hanley N. Abramson, " Crystal and Molecular Structure of (dl)-Azabiotin Hydrochloride, The Nitrogen Analog of Biotin," Acta Crystallographica, B33, 1095-1101 (1977).
  14. C.L. Huang, H.N. Abramson, and Y.M. Wang, "The Effect of Digitoxigenin Thioacetate on the Heart," IRCS Medical Science: Library Compendia, 5, 20 (1977).
  15. Hanley N. Abramson and Henry C. Wormser, "Synthesis of Nectriapyrone," Journal of Heterocyclic Chemistry, 18, 363-366 (1981).
  16. David L. Vesely, Henry C. Wormser, and Hanley N. Abramson, "Biotin Analogs Activate Guanylate Cyclase," Molecular and Cellular Biochemistry, 60, 109 (1984).
  17. J.W. Banning, J.P. Nachtman, E.T. Roginski, J.D. Wu, H.N. Abramson, and H.C. Wormser, "Comparison of DNA Binding and Cardiac Superoxide Production by Anthraquinonyl Glucosaminosides and Daunomycin," The Pharmacologist, 26, 148 (1984).
  18. J.P. Nachtman, E.T. Roginski, J.W. Banning, H.N. Abramson, and H.C. Wormser, "DNA Binding and Cardiac Superoxide Production Studies of Pyridoanthraquinones," Toxicologist, 4, 53 (1984).
  19. J.P. Nachtman, E.T. Roginski, J.W. Banning, H.C. Wormser, H.N. Abramson, and T.H. Corbett, "DNA Binding, Cardiac Superoxide Production and Cytotoxicity of Daunomycin Analogs," Research Communications in Chemical Pathology and Pharmacology, 47, 73-83 (1985).
  20. H.N. Abramson, J.W. Banning, J.P. Nachtman, E.T. Roginski, M. Sardessai, H.C. Wormser, J.D. Wu, Z. Nagia, R.R. Schroeder, and M.M.Bernardo, "Synthesis of Anthraquinonyl Glucosaminosides and Studies on the Influence of Aglycone Hydroxyl Substitution on Superoxide Generation, DNA Binding, and Antimicrobial Properties," Journal of Medicinal Chemistry, 29, 1709-1714 (1986).
  21. J.W. Banning, H.N. Abramson, H.C. Wormser, J.D. Wu, and T.H. Corbett, "Relative Cardiotoxicity and Cytotoxicity of Anthraquinonyl Glucosaminosides," Cancer Chemotherapy and Pharmacology, 19 , 207-212 (1987).
  22. M.T. Furlong, H.N. Abramson, N.A. Akamike, and H.C. Wormser, "Approach to Aminated Anthracyclines via an Intramolecular Marschalk Reaction," Synthetic Communications, 20, 2691-2697 (1990).
  23. M. Sardessai and H.N. Abramson, "The Bromination of 2,5-Dimethoxybenzaldehyde: Structural Proof of the 6-Bromo Isomer via Synthesis of 3,6-Dimethoxybenzocyclobutene," Organic Preparations and Procedures International, 23 , 419-424 (1991).
  24. H.C. Wormser, M.S. Sardessai, and H.N. Abramson, "A Facile Method for Preparing Substituted 1-Aminoanthraquinones," Synthetic Communications, 23, 3211-3222 (1993).
  25. M.S. Sardessai, H.N. Abramson, and H.C. Wormser, "Synthesis of Aminated Naphthacenetriones: Precursors to Aminated Anthracyclines," Synthetic Communications, 23, 3223-3229 (1993).
  26. H.N. Abramson, "The Lipogenesis Pathway as a Cancer Target," Journal of Medicinal Chemistry, 54, 5615-5638 (2011). Impact Factor: 5.207
  27. H. N. Abramson, “Kinase Inhibitors as Potential Agents in the Treatment of Multiple Myeloma”, Oncotarget. 7 (49), 81926-81968 (2016). Impact Factor: 6.359
  28. H.N. Abramson, "The Multiple Myeloma Drug Pipeline:2018. A Review of Small Molecules and their Therapeutic Targets". Clinical Lymphoma, Myeloma, and Leukemia. 18 (9). 611-627 (2018).. Impact Factor: 2.308 (2017/2018)
  29. H.N. Abramson, "Monoclonal Antibodies for the Treatment of Multiple Myeloma: an Update."  International Journal of Molecular Sciences. 19. 3924 (31 pages) (2018). Impact Factor 3.687 (2017).
  30. H.N. Abramson, “B-Cell Maturation Antigen (BCMA) as a Target for New Drug Development in Relapsed and/or Refractory Multiple Myeloma.” International Journal of Molecular Sciences. 21. 5192 (24 pages) (2020). Impact Factor 4.556 (2019).
  31. H.N. Abramson, Book Chapter 7 (20 pages): “Emerging Monoclonal Antibodies for the Treatment of Multiple Myeloma.”  in “Monoclonal Antibodies”,  Nima Rezaei, Ed. (ISBN: 978-1-83968-370-1); InTechOpen (2020).
  32. H.N. Abramson. "Immunotherapy of Multiple Myeloma: Promise and Challenges". ImmunoTargets and Therapy. 10, 343-371 (2021). Impact Factor 4.147 (2020).
  33. H.N. Abramson, Recent Advances in the Applications of Small Molecules in the Treatment of Multiple Myeloma". International Journal of Molecular Sciences. 24. 2645 (29 pages) (2023). Impact Factor 6.208 (2021).

 

Professional Publications

  1. Hanley N. Abramson and Henry Wormser, "Migraine, " The Michigan Pharmacist, Jan. 1972, p. 14.
  2. Hanley Abramson and Henry Wormser, "Glaucoma," The Michigan Pharmacist , May 1972, p. 13.
  3. Hanley Abramson and Henry Wormser, "Psoriasis," The Michigan Pharmacist , May 1972, p. 14.
  4. Henry Wormser and Hanley Abramson, "Bronchial Asthma - Part I", The Michigan Pharmacist , August 1972, p. 20.
  5. Henry Wormser and Hanley Abramson, "Bronchial Asthma - Part II", The Michigan Pharmacist , Nov.1972, p. 23.
  6. Hanley N. Abramson and Henry Wormser, "Drugs and Pregnancy - Part I," The Michigan Pharmacist , Jan. 1973, p. 12.
  7. Hanley Abramson and Henry Wormser, "Drugs and Pregnancy - Part II," The Michigan Pharmacist , Mar. 1973, p. 10.
  8. Hanley Abramson and Henry Wormser, "Drugs and Pregnancy - Part III," The Michigan Pharmacist , May 1973, p. 10.
  9. Hanley Abramson, "Ethical Concerns in Drug Research," in "The Scientist and Ethical Decisions," Charles Hatfield, ed., Inter-Varsity Press, Downers Grove , Ill. , 1973, pp. 49-56.
  10. Henry C. Wormser and Hanley N. Abramson, "Atherosclerosis and Antilipemic Agents," The Apothecary, April 1974, p.26-28.
  11. Henry C. Wormser and Hanley Abramson, "A Review of Digitalis Therapy," U.S. Pharmacist , 2, October 1977, p. 50-59.
  12. Henry C. Wormser and Hanley N. Abramson, "Drugs for Pinworm Infestation," U.S. Pharmacist, 2 , October 1977, p. 44-53.
  13. H.N. Abramson, H.C. Wormser, and M. Taylor-Wehr, "Therapeutic Uses of Oral Zinc," U.S. Pharmacist, 4 , April 1979, p.61-66.
  14. Hanley N. Abramson, Book Review of "Contemporary Organic Chemistry" by Andrew L. Ternay, American Journal of Pharmaceutical Education, 45, 93 (1981).
  15. Hanley N. Abramson, Book Review of "Contemporary Heterocyclic Chemistry" by George R. Newkome and William W. Paudler, American Journal of Pharmaceutical Education, 47, 191 (1983).
  16. Hanley N. Abramson, Book Review of "Solvents and Solvent Effects in Organic Chemistry, Second Edition", by ChristianReichardt, American Journal of Pharmaceutical Education, 53, 210 (1989).
  17. Hanley N. Abramson, Book Review of "Chirality and Biological Activity" by B. Holmstedt, H. Frank, and B. Testa, American Journal of Pharmaceutical Education, 54, 495-496 (1990).
  18. Hanley N. Abramson, "The Pharm.D. Entry-Level Degree Issue: A Faculty Member's View," Journal Michigan Pharmacist , 29, 85-86 (1991).
  19. Hanley N. Abramson, "Basic Techniques in Recombinant DNA Technology," Pharmacy Practice News, March, 1992, p. 8, 17-18.

 

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