Degrees and Certifications

• 2021 - Certificate in Applied Biostatsitics, Harvard University Catalyst
• 2019 - Certificate in Clinical Research Conduct & Management, University of California Berkeley Ext.
• 2014 - American College of Clinical Pharmacy Focused Investigator Training Program
• 2013 - MI Regional Comprehensive Metabolomics Resource Cores Summer Metabolomics Workshop
• 2012 - Institute of General Medical Sciences 2nd Annual Short Course on Statistical, Genetics & Genomics
• 2012 - Statistical Analysis with R Workshop, Michigan Center for Statistical Consultation and Research

Positions and Employment

• 2020-present - Associate Professor of Pharmacy Practice - Tenured, Wayne State University Eugene Applebaum College of Pharmacy and Health Sciences
• 2014-2020 - Assistant Professor of Pharmacy Practice - Tenure Track, Wayne State University Eugene Applebaum College of Pharmacy and Health Sciences
• 2011-2014 - Pharmacist at Schmidt and Sons Pharmacy (Tecumseh, MI)
• 2009 - Research Assistant with the Highland Park Project under the Ginsberg Research Grant, University of Michigan College of Pharmacy, Department of Clinical, Social and Administrative Sciences
• 2005-2006 - Research Assistant in the Molecular and Behavioral Neuroscience Institute Watson/Akil Lab, University of Michigan School of Medicine

Awards and Honors

• 2024 - Journal of Neuroscience Research top 10 most-cited papers published (J Neurosci Res. 2022 publication)
• 2024 - The Gary A. Dudley Memorial Paper Scientific Manuscript Excellence Honor (J Strength Cond Res 2024 publication)
• 2020 - American College of Clinical Pharmacy New Investigator 2020 Award
• 2019 - Original Research Award Winner for College of Psychiatric and Neurologic Pharmacist Association
• 2017 - American College of Clinical Pharmacy Poster Accepted for CE presentation
• 2016 - Wayne State University Eugene Applebaum College of Pharmacy and Health Sciences College Research Day Poster Award (Mentor to Brittany Lines)
• 2016 - Undergraduate Research Opportunity Program Grant (Mentor to Nadeen Mansour)
• 2016 - American College of Clinical Pharmacy New Investigator Award Nomination
• 2015 - College of Psychiatric and Neurologic Pharmacist Original Research Award
• 2014 - American Society of Clinical Psychopharmacology (ACSP) Annual Meeting - New Investigator Award recipient
• 2014 - Poster Award Finalist at the Schizophrenia International Research Society 2014 Meeting
• 2012 - Travel Fellowship Award for National Institute of General Medical Sciences 2nd Annual Short Course on Statistical Genetics and Genomics
• 2011 - Doctor of Pharmacy: Community Service Award
• 2009-2010 - Gertrude and George Huebner Scholarship
• 2010 - R.A. Deno Award for Significant Improvement in Scholarship

Professional Memberships

• 2014-present - American Association of Colleges of Pharmacy
• 2011-present - American College of Clinical Pharmacy
• 2009-present - College of Psychiatric and Neurologic Pharmacists

Areas of Expertise

• Pharmacoepigenetics
• Metabolomics
• Lipidomics
• Antipsychotics
• Insulin resistance

Primary Research Interest

Active

• 2024 American Association of Colleges of Pharmacy New Investigator Grant – Mentor on grant (PI: Adeosun Samuel): Amount: $10,000

• 2024 Commission on Dietetic Registration Emerging Researcher Grant. Academy of Nutrition and Dietetics Foundation – Co-Investigator on grant (PI: Maria Dingh) Amount: $10,000

• 2023 District IV National Association Boards of Pharmacy/American Association of Colleges of Pharmacy Grant Award to Pharmacy Students – Co-mentor on grant (PI: Shannon Habba). Amount: $4,500

Completed 

• American Association of Colleges of Pharmacy Science of Teaching and Learning Grant.“ Effects of Hands-On Personalized Genetic Testing in Pharmacogenetics Education” Role: Primary Investigator (5%) Amount: $4500

• NIH K23 Patient-Oriented Career Development Award. Funding IC: NIDDK - K23DK118199 “Acutely Induced Insulin Resistance by Antipsychotic Medication in Healthy Volunteers: Impact of Skeletal Muscle Epigenomic and Proteomic Mechanisms” Role: PI (75%) Amount: $675,168

• NIH K23 Retention Supplement. Funding IC: NIDDK - K23DK118199S1. Supplement to “Acutely Induced Insulin Resistance by Antipsychotic Medication in Healthy Volunteers: Impact of Skeletal Muscle Epigenomic and Proteomic Mechanisms” Role: PI (75%) Amount: $53,887

• National Institutes of Health Loan Repayment Program for Extramural Clinical Research. Funding IC: National Institute of Diabetes Digestive and Kidney Diseases (NIDDK) “Mechanisms of antipsychotic-induced insulin resistance in the skeletal muscle." NIH - L30 DK110823 Role: Primary Investigator. Amount: $112,422.99 (renewed in 2018 and 2019 and 2020)

Recent Publications

• Howlett BH, Kassa M, Burghardt KJ*. 1st ed. Machado-Vieira R and Soares JC (Editors). Elsevier (New York); 2022. Biomarkers in Bipolar Disorders. Chapter 15. DNA Methylation in Bipolar Disorder. Pgs. 267-286.

Refereed Journals

• Burghardt KJ*, Burghardt PR, Howlett BH, Dass SE, Zahn B, Imam A, Mallisho A, Msallaty Z, Seyoum B, Yi Z. Alterations in Skeletal Muscle Insulin Signaling DNA Methylation. A Pilot Randomized Controlled Trial of Olanzapine in Healthy Volunteers. Biomedicines 2024, 12, 1057.

• Arroum T, Hish GA, Burghardt KJ, McCully JD, Hüttemann M**, Malek MH**. (**Designates co-senior authors). Mitochondrial Transplantation’s Role in Rodent Skeletal Muscle Bioenergetics: Recharging the Engine of Aging. Biomolecules 2024, xxxxxx

• Stewart B*, Habba S, Burghardt KJ. Michigan Pharmacists Association. The Official Journal of the Michigan Pharmacists Association. 2024. Apr 14; 62(2): 16-17

• Arroum, T., G. A. Hish, K. J. Burghardt, M. Ghaloush, B. Bazzi, A. Mrech, P. T. Morse, S. L. Britton, L. G. Koch, J. D. McCully, M. Hüttemann**, M. H. Malek**. (**Designates co-senior authors). Mitochondria transplantation: rescuing innate muscle bioenergetic impairment in a model of aging and exercise intolerance. J Strength Cond Res, x(x): xxxx-xxxx, in press (paper given award - see award section).

• Burghardt KJ*, Kajy M, Ward KM, Burghardt PR. Metabolomics, Lipidomics, and Antipsychotics: A Systematic Review. Biomedicines 2023, 11(12), 3295.

• Rowbal T, Kajy M, Burghardt KJ*. Epigenome-Wide Studies of Antipsychotics: A Systematic Review and Pathway Meta-Analysis. Epigenomics. 2023 Oct;15(20):1085-1094.

• Burghardt KJ*, Mando M, Seyoum B, Yi Z, Burghardt PR. The Effect of Antipsychotic Treatment on Hormonal, Inflammatory and Metabolic Biomarkers in Healthy Volunteers; A Systematic Review and Meta-Analysis. Accepted. In Press.

• Burghardt KJ*, Calme G, Caruso M, Howlett BH, Sanders E, Zhang X, Msallaty Z, Mallisho A, Seyoum B, Qi YA, Yi Z. Profiling the Skeletal Muscle Proteome in Patients on Atypical Antipsychotics and Mood Stabilizers. Brain Sciences (MDPI). 2022; 12(2):259.

• Zabik NL, Iadipaolo AS, Marusak HA, Peters C, Burghardt KJ, Rabinak CA*. A Common Genetic Variant in Fatty Acid Amide Hydrolase is Linked to Alterations in Fear Extinction Neural Circuitry in a Racially Diverse, Non-Clinical Sample of Adults. Journal of Neuroscience Research. 2022 Mar;100(3):744-761.

• Mestareehi A, Zhang X, Seyoum B, Msallaty Z, Abdullah Mallisho A, Burghardt KJ, Kowluru A, Yi Z*. Metformin Increases Protein Phosphatase 2A Activity In Primary Human Skeletal Muscle Cells Derived from Lean Healthy Participants. Journal of Diabetes Research (Hindawi). 2021 Jul 28;2021:9979234.

• Ward KM*, Burghardt KJ, Kraal AZ, Jaeger A, Yeomans L, Mchugh C, Karnovsky A, Stringer KA, Ellingrod VL. Genetic and Metabolite Variability in One-Carbon Metabolism Applied to an Insulin Resistance Model in Patients with Schizophrenia Receiving Atypical Antipsychotics. Frontiers Neuroscience. 2021 May 25;12:623143.

• Burghardt KJ*, Ward KM, Howlett BH, Burghardt PR. Personal Genotyping and Student Outcomes in Genetic and Pharmacogenetic Teaching; A Systematic Review and Meta-Analysis. Pharmacogenomics (Futures Medicine). 2021 May;22(7):423-433

• Ward KM*, Taubman DS, Pasternak AL, Burghardt KJ, Ellingrod VL, Parikh SV. Teaching Psychiatric Pharmacogenomics Effectively: Evaluation of a Novel Interprofessional Online Course. Journal of the American College of Clinical Pharmacy. February 2021. 4(2). 176-183.

• Burghardt KJ*, Howlett BH, Khoury A., Fern SM, Burghardt PR. Bibliometric data based on the Pharm.D. and Ph.D. degree in United States research-intensive colleges of pharmacy. International Journal of Pharmacy Practice. 2021 Feb 10;29(1):78-83.

• Burghardt KJ*, Howlett BH, Khoury A., Fern SM, Burghardt PR. Three Commonly Utilized Scholarly Databases and a Social Network Site Provide Different, but Related, Metrics of Pharmacy Faculty Publication. Publications 2020, 8(2), 18.

• Burghardt KJ*, Khoury A, Msallaty Z, Yi Z, Seyoum B. Antipsychotic Medications and DNA Methylation in Schizophrenia and Bipolar Disorder: A Systematic Review. Pharmacotherapy. Accepted 1/24/2020.

• Burghardt KJ*, Howlett BH, Fern SM, Burghardt PR. A Bibliometric Analysis of the Top 50 NIH-Funded Colleges of Pharmacy Using Two Databases. Research in Social and Administrative Pharmacy. 2019 Oct 9. pii: S1551-7411(19)30677-1.

• Burghardt KJ*, Howlett BH, Sanders E, Dass SE, Msallaty Z, Mallisho A, Seyoum B, Yi Z. Skeletal Muscle DNA Methylation Modifications and Psychopharmacologic Treatment in Bipolar Disorder. European Neuropsychopharmacology. 2019 Oct 18. pii: S0924-977X(19)31700-6.

• Kraal, AZ*, Moll AC, Arvanitis NR, Ward KM, Dougherty RJ, Grove TB, Burghardt KJ, Ellingrod VL. Metabolic Syndrome is Negatively Associated with Cognition among Endothelial Nitric Oxide Synthase (eNOS)-786C carriers in Schizophrenia-Spectrum Disorders. Journal of Psychiatric Research. 2019 Oct;117:142-147.

Non-Refereed Journals

• Stewart B*, Habba S, Burghardt KJ. Michigan Pharmacists Association. The Official Journal of the Michigan Pharmacists Association. 2024. Apr 14; 62(2): 16-17

Courses taught by Kyle Burghardt, Pharm.D.

Fall Term 2024 (current)

• PHA4125 - Drug Literature Evaluation and Foundations of Research

Spring-Summer Term 2024

• PHA5110 - Pharmacogenomics

Winter Term 2024

• PPR5215 - Applied Pharmacokinetics and Pharmacogenomics

Spring-Summer Term 2023

• PHA5110 - Pharmacogenomics

Winter Term 2023

• PPR5215 - Applied Pharmacokinetics and Pharmacogenomics

Spring-Summer Term 2022

• PHA5110 - Pharmacogenomics

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