Jiemei Wang, M.D., Ph.D.

Associate Professor

Office Location

EACPHS, Suite 3122

Phone

313-577-1715

Email

jiemei.wang@wayne.edu

Department

Pharmaceutical Sciences

Research website

https://orcid.org/0000-0002-8723-4410

Website

https://www.ncbi.nlm.nih.gov/myncbi/jie-mei.wang.1/bibliography/public/

Jiemei Wang, M.D., Ph.D.

Biography

Degrees and Certifications

2004: M.D., Clinical Medicine, Sun Yat-Sen University, Guangzhou, China
2009: Ph.D., Internal Medicine (Cardiology), Sun Yat-Sen University, Guangzhou, China
2010: AHA Postdoctal fellowship, University of Pittsburgh, Pittsburgh, PA, USA

Positions and Employment

2021.8 - present: Associate Professor with Tenure, Department of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, MI
2016.5 - 2021.8: Assistant Professor - Tenure track, Department of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, MI
2014.7 - 2016.5: Assistant Professor - Research, Center for Molecular Medicine & Genetics Wayne State University, Detroit, MI
2012 - 2014.7: Research Instructor and Research Assistant Professor, Department of Surgery, University of Pittsburgh, Pittsburgh, PA
2011 - 2015: Research Associate, VA Vascular Surgery Research VA Pittsburgh Healthcare System Pittsburgh, PA

Awards and Honors

2024-American Heart Association Established Investigator Award
2021-EACPHS Junior Faculty Research Recognition Award
2017-Wayne State University Cardiovascular Research Institute Award
2016-Wayne State University Faculty Orientation Treasure Hunt Winner
2013-American Heart Scientist Development Award
2011-Distinguished Speaker, 4th Annual Translational to Clinical (T2C) Wound Care Conference. Columbia, OH.
2010-The Wound Biotechnology Foundation Travel Award for Trainees, Wound Healing Society. Orlando, FL.
2010-Second place in Basic Science, American Heart Association Research Day, Pittsburgh, PA.
2009-American Heart Association Midwest Postdoctoral Award
2009-NanYue Award to Outstanding Graduate, Guangzhou, China.
2008-Scientific Sessions Merit Travel Award for Young Investigators, American Heart Association, New Orleans, LA.
2004Physician Excellence Training Award, Sun Yat-Sen University, Guangzhou, China

Professional Memberships

American Heart Association
Wound Healing Society
American Society for Pharmacology and Experimental Therapeutics
American Diabetes Association
American Physiology Society
Rho Chi Society

Areas of Expertise

Diabetes
Cardiovascular disorders
Angiogenesis
Endothelium
Stress signaling

Primary Research Interest

Endothelial Cell Function and Angiogenesis: The researcher has extensive expertise in understanding how endothelial cells (ECs) function, particularly in the context of metabolic disorders such as diabetes and obesity. This includes the investigation of molecular pathways affecting ECs, such as oxidative stress, microRNAs, and G protein-coupled receptors (e.g., GPR35), with a focus on how these factors influence angiogenesis and wound healing.

Molecular Mechanisms in Diabetic Complications: A major focus is on the molecular mechanisms that underlie diabetic complications, particularly in relation to wound healing. The researcher has explored how chronic hyperglycemia affects endothelial cell function and neovascularization, identifying key molecules like the unfolded protein response (UPR) and oxidative stress pathways as therapeutic targets for improving wound healing in diabetes.

Regulation of Endothelial Permeability and Vascular Dysfunction: The researcher has also contributed to understanding how endothelial permeability is altered under metabolic stress, such as in hyperglycemia. This includes studies on how microRNAs, such as miR-466 and miR-200, affect endothelial barrier function, contributing to vascular dysfunction and complications like diabetic retinopathy and atherosclerosis.

Therapeutic Strategies and Pharmacological Interventions: The researcher has been involved in the development of therapeutic strategies targeting molecular pathways in ECs to promote wound healing and vascular health, particularly through the modulation of GPR35, oxidative stress responses, and the use of natural compounds like resveratrol and hesperetin to enhance endothelial function and angiogenesis.

Recent Publications

1. Minjares M, Thepsuwan P, Kezhong Zhang*, Wang JM*. Unfolded Protein Responses: Dynamic Machinery in Wound Healing. Invited Review. Pharmacology & Therapeutics 2024. Impact factor 13.5. Revision to be resubmitted in December 2024

2. Yang Z, Wang JM, Qiu Y, Song Z, Chen Q, Zhang X, Zhou J, Mi !, Heng H, Yi Z, Chen L, Sun Q, Chen X, Li L, Zhang R, Zhang K. Inhalation Exposure to Airborne PM2.5 Attenuates Hepatic Metabolic Pathways through S-Nitrosylation of the Primary ER Stress Sensor. Am J Physiol Cell 2024. Impact factor 5.2. Accepted.

3. Li H, Xu L, Meda Venkata SP, Minjares M, Melhem H, Kowluru A, Niess JH, Milligan G, and Wang JM*. Inhibition of G protein-coupled receptor 35 promotes angiogenesis through activating oxidative stress response 1 in diabetic wounds. Diabetes 2024. Impact factor 6.2 Under major revision.

4. SP Meda Venkata, Li H, Xu L, Wang JM*. The Impact of Obesity on Diabetes Onset and Neovascularization in Mouse Models of Metabolic Stress. International Journal of Molecular Sciences 2024 Jan 19;25(2):1214. PMID: 38279212 PMCID: PMC10816627; Impact factor 5.6

5. Wang JM*. Reply to Doboszewska et al.: The many faces of G-protein-coupled receptor 39. Proc Natl Acad Sci U S A. 2023 Jul 11;120(28):e2308643120. Epub 2023 Jul 3. PubMed PMID: 37399406; PubMed Central PMCID: PMC10334786. Impact factor 12.78

6. Minjares M, Wu W, Wang JM*. Oxidative Stress and MicroRNAs in Endothelial Cells under Metabolic Disorders. Cells. 2023 May 8;12(9). Review. PubMed PMID: 37174741; PubMed Central PMCID: PMC10177439. Impact factor 7.666.

7. Mestareehi A, Li H(Co-1st), Zhang X, Meda Venkata SP, Jaiswal R, Yu FS, Yi Z*, Wang JM*. Quantitative Proteomics Reveals Transforming Growth Factor β Receptor Targeted by Resveratrol and Hesperetin Coformulation in Endothelial Cells. ACS Omega. 2023 May 9;8(18):16206-16217. eCollection 2023 May 9. PubMed PMID: 37179642; PubMed Central PMCID: PMC10173440. Impact factor 4.132

8. Wang JM*, Li H, Xu L, Kim H, Qiu Y, Zhang K*. Boosting UPR Transcriptional Activator XBP1 Accelerates Acute Wound Healing. Proceedings of the National Academy of Sciences (PNAS) Nexus 2023 Feb 14;2(3):pgad050. Impact factor 11.205

9. Meda Venkata SP, Li H, Xu L, Koh JY, Nguyen H, Minjares M, Li C, Kowluru A, Milligan G, Wang JM*. Inhibition of GPR39 restores defects in endothelial cell-mediated neovascularization under the duress of chronic hyperglycemia: Evidence for regulatory roles of the sonic hedgehog signaling axis. Proc Natl Acad Sci U S A. 2023 Jan 3;120(1):e2208541120. Epub 2022 Dec 27. PubMed PMID: 36574661. Impact factor 12.78

10. Kujawa M, O'Meara M, Li H, Xu L, Meda Venkata SP, Nguyen H, Minjares M, Zhang K, Wang JM*. MicroRNA-466 and microRNA-200 increase endothelial permeability in hyperglycemia by targeting Claudin-5. Mol Ther Nucleic Acids. 2022 Sep 13;29:259-271. eCollection 2022 Sep 13. PubMed PMID: 35892090; PubMed Central PMCID: PMC9307898. Impact factor 8.886

11. Li H, Nguyen H, Meda Venkata SP, Koh JY, Kowluru A, Li L, Rossi NF, Chen W, Wang JM*. Novel Role of GPR35 (G-Protein-Coupled Receptor 35) in the Regulation of Endothelial Cell Function and Blood Pressure. Hypertension. 2021 Sep;78(3):816-830. Epub 2021 Jul 19. PubMed PMID: 34275335; PubMed Central PMCID: PMC8357038. Impact factor 10.19

12. Nguyen H, Koh JY, Li H, Islas-Robles A, Meda Venkata SP, Wang JM*, Monks TJ*. A novel imidazolinone metformin-methylglyoxal metabolite promotes endothelial cell angiogenesis via the eNOS/HIF-1α pathway. FASEB J. 2021 Jul;35(7):e21645. PubMed PMID: 34105824; PubMed Central PMCID: PMC8237315. Impact factor 4.966.

13. Li H, O'Meara M, Zhang X, Zhang K, Seyoum B, Yi Z, Kaufman RJ, Monks T, Wang, JM*. Ameliorating Methylglyoxal-Induced Progenitor Cell Dysfunction for Tissue Repair in Diabetes. Diabetes 68(6): 1287-1302, 2019. Impact factor: 8.784

14. Wang Y, Hall LM, Kujawa M, Li H, Zhang X, Megan OM, Ichinose T, Wang JM*. Methylglyoxal Triggers Human Aortic Endothelial Cell Dysfunction via Modulating KATP/MAPK pathway. American Journal of Physiology – Cell Physiology: C68-81, 2019. Impact factor: 3.4

15. Wang JM*, Qiu Y, Zhao Y, Kim HB, Qian Q, Sun Q, Zhang C, Yin L, Fang D, Back SH, Kaufman RJ, Yin L*, Zhang K*. Inositol Requiring Enzyme 1 Prevents Hepatic Steatosis through Processing MicroRNAs. Science Signaling 11(530): eaao4617, 2018 Impact factor: 6.494.

16. Farooq SM, Hou Y, Li H, Wang Y, Li CY*, Wang JM*. Disruption of GPR35 Exacerbates Dextran Sulfate Sodium-induced Colitis in Mice. Digestive Diseases and Sciences, 63(11):2910-2922, 2018. Impact factor: 2.875

17. Sun H, Lee P, Yan C, Gao N, Wang JM, Fan X, Yu FS. Inhibition of Soluble Epoxide Hydrolase 2 Ameliorates Diabetic Keratopathy and Impaired Wound Healing in Mouse Corneas. Diabetes 67(8), 1162-1172, 2018. Impact factor: 8.784.

18. Zhang K, Kim H, Fu Z, Qiu Y, Yang Z, Wang JM, Zhang D, Tong X, Yin L, Li J, Wu J, Qi NR, Houten SM, Zhang R. Deficiency of the Mitochondrial NAD Kinase Causes Stress-induced hepatic steatosis in mice. Gastroenterology 154(1): 224-237, 2018. Impact factor: 18.392

19. Li H, Liu J, Wang Y, Fu Z, Huttemann M, Monks TJ, Chen AF, Wang JM*. MiR-27b augments bone marrow progenitor cell survival via suppressing the mitochondrial apoptotic pathway in type 2 diabetes. American Journal of Physiology-Endocrinology and Metabolism 313: E391-E401, 2017 Impact factor: 4.142

20. Wang JM*, Qiu YN, Yang ZQ, Li L, Zhang K*. Inositol requiring enzyme 1α facilitates diabetic wound healing through modulating microRNAs. Diabetes 66:177-192, 2017. Impact factor: 8.784.