Jiemei Wang, M.D., Ph.D.

Associate Professor

Office Location

EACPHS, Suite 3122

Phone

313-577-1715

Email

jiemei.wang@wayne.edu

Department

Pharmaceutical Sciences

Research website

https://orcid.org/0000-0002-8723-4410

Website

https://www.ncbi.nlm.nih.gov/myncbi/jie-mei.wang.1/bibliography/public/

Jiemei Wang, M.D., Ph.D.

Biography

Degrees and Certifications

2004: M.D., Clinical Medicine, Sun Yat-Sen University, Guangzhou, China
2009: Ph.D., Internal Medicine (Cardiology), Sun Yat-Sen University, Guangzhou, China
2010: AHA Postdoctal fellowship, University of Pittsburgh, Pittsburgh, PA, USA

Positions and Employment

2021.8 - present: Associate Professor, Department of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, MI
2016.5 - 2021.8: Assistant Professor, Department of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, MI
2014.7 - 2016.5: Assistant Professor - Research, Center for Molecular Medicine & Genetics Wayne State University, Detroit, MI
2012 - 2014.7: Research Instructor and Research Assistant Professor, Department of Surgery, University of Pittsburgh, Pittsburgh, PA
2011 - 2015: Research Associate, VA Vascular Surgery Research VA Pittsburgh Healthcare System Pittsburgh, PA

Awards and Honors

2011: Distinguished Speaker, 4th Annual Translational to Clinical (T2C) Wound Care Conference. Columbia, OH.
2010: The Wound Biotechnology Foundation Travel Award for Trainees, Wound Healing Society. Orlando, FL.
2010: Second place in Basic Science, The American Heart Association and the Fellows Research Day, Pittsburgh, PA.
2009: American Heart Association (AHA) Postdoctoral Fellowship Award, Pittsburgh, PA.
2008: Scientific Sessions Merit Travel Award For Young Investigators, American Heart Association, New Orleans, LA
2007: China Overseas Doctoral Scholarship Award, Guangzhou, China.
2004: Physician Excellence Training Award, Sun Yat-Sen University, Guangzhou, China

Professional Memberships

American Heart Association
Wound Healing Society
American Society for Pharmacology and Experimental Therapeutics
American Diabetes Association
American Physiology Society
Rho Chi Society

Areas of Expertise

Diabetes
Cardiovascular disorders
Angiogenesis
Endothelium
Stress signaling

Primary Research Interest

There are two major focuses in my research:

Non-coding RNA regulation of tissue regeneration. MicroRNAs are newly discovered short oligonucleotides that act as key regulators of gene expression. It is until recently that the importance of microRNA-directed gene regulation in vascular disorders has been recognized. Our project is to determine the biogenesis of miRNAs and their impact on tissue repair, in response to detrimental stress, such as diabetes, hyperlipidemia, hypertension, etc. We are working on new projects to look at some of the long non-coding RNAs (lncRNA) in regulation of anigogenesis as well.
Endothelial injury and repair in disease settings. The well-being of vascular endothelium is essential to normal vascular homeostasis. Its dysfunction is one of the first steps leading to atherosclerosis. Endothelial progenitor cells (EPCs) are vascular endothelial cell (EC) precursors that are capable of differentiating into mature endothelial cells and producing new vessels but their functions are impaired in various cardiovascular diseases. We are investigating the morphogenic activities of EPCs that might contribute to EPCs’ therapeutic potentials for wound healing.

Recent Publications

1. Meda Venkata, Li H, Xu L, Wang JM*. The Impact of Obesity on Diabetes Onset and Neovascularization in Mouse Models of Metabolic Stress. International Journal of Molecular Sciences 2024, online. Impact factor 5.6

2. Wang JM*. Reply to Doboszewska et al.: The many faces of G-protein-coupled receptor 39. Proc Natl Acad Sci U S A. 2023 Jul 11;120(28):e2308643120. Epub 2023 Jul 3. PubMed PMID: 37399406; PubMed Central PMCID: PMC10334786. Impact factor 12.78

3. Minjares M, Wu W, Wang JM*. Oxidative Stress and MicroRNAs in Endothelial Cells under Metabolic Disorders. Cells. 2023 May 8;12(9). Review. PubMed PMID: 37174741; PubMed Central PMCID: PMC10177439 Impact factor 7.666.

4. Mestareehi A, Li H(Co-1st), Zhang X, Meda Venkata SP, Jaiswal R, Yu FS, Yi Z*, Wang JM*. Quantitative Proteomics Reveals Transforming Growth Factor β Receptor Targeted by Resveratrol and Hesperetin Coformulation in Endothelial Cells. ACS Omega. 2023 May 9;8(18):16206-16217. eCollection 2023 May 9. PubMed PMID: 37179642; PubMed Central PMCID: PMC10173440. Impact factor 4.132

5. Wang JM*, Li H, Xu L, Kim H, Qiu Y, Zhang K*. Boosting UPR Transcriptional Activator XBP1 Accelerates Acute Wound Healing. Proceedings of the National Academy of Sciences (PNAS) Nexus 2023 Feb 14;2(3):pgad050. Impact factor 11.205

6. Meda Venkata SP, Li H, Xu L, Koh JY, Nguyen H, Minjares M, Li C, Kowluru A, Milligan G, Wang JM*. Inhibition of GPR39 restores defects in endothelial cell-mediated neovascularization under the duress of chronic hyperglycemia: Evidence for regulatory roles of the sonic hedgehog signaling axis. Proc Natl Acad Sci U S A. 2023 Jan 3;120(1):e2208541120. Epub 2022 Dec 27. PubMed PMID: 36574661. Impact factor 12.78

7. Kujawa M, O'Meara M, Li H, Xu L, Meda Venkata SP, Nguyen H, Minjares M, Zhang K, Wang JM*. MicroRNA-466 and microRNA-200 increase endothelial permeability in hyperglycemia by targeting Claudin-5. Mol Ther Nucleic Acids. 2022 Sep 13;29:259-271. eCollection 2022 Sep 13. PubMed PMID: 35892090; PubMed Central PMCID: PMC9307898. Impact factor 8.886

8. Li H, Nguyen H, Meda Venkata SP, Koh JY, Kowluru A, Li L, Rossi NF, Chen W, Wang JM*. Novel Role of GPR35 (G-Protein-Coupled Receptor 35) in the Regulation of Endothelial Cell Function and Blood Pressure. Hypertension. 2021 Sep;78(3):816-830. Epub 2021 Jul 19. PubMed PMID: 34275335; PubMed Central PMCID: PMC8357038. Impact factor 10.19

9. Nguyen H, Koh JY, Li H, Islas-Robles A, Meda Venkata SP, Wang JM*, Monks TJ*. A novel imidazolinone metformin-methylglyoxal metabolite promotes endothelial cell angiogenesis via the eNOS/HIF-1α pathway. FASEB J. 2021 Jul;35(7):e21645. PubMed PMID: 34105824; PubMed Central PMCID: PMC8237315. Impact factor 4.966.

10. Li H, O'Meara M, Zhang X, Zhang K, Seyoum B, Yi Z, Kaufman RJ, Monks T, Wang, JM*. Ameliorating Methylglyoxal-Induced Progenitor Cell Dysfunction for Tissue Repair in Diabetes. Diabetes 68(6): 1287-1302, 2019. Impact factor: 8.784

11. Wang Y, Hall LM, Kujawa M, Li H, Zhang X, Megan OM, Ichinose T, Wang JM*. Methylglyoxal Triggers Human Aortic Endothelial Cell Dysfunction via Modulating KATP/MAPK pathway. American Journal of Physiology – Cell Physiology: C68-81, 2019. Impact factor: 3.4

12. Wang JM*, Qiu Y, Zhao Y, Kim HB, Qian Q, Sun Q, Zhang C, Yin L, Fang D, Back SH, Kaufman RJ, Yin L*, Zhang K*. Inositol Requiring Enzyme 1 Prevents Hepatic Steatosis through Processing MicroRNAs. Science Signaling 11(530): eaao4617, 2018 Impact factor: 6.494.

13. Farooq SM, Hou Y, Li H, Wang Y, Li CY*, Wang JM*. Disruption of GPR35 Exacerbates Dextran Sulfate Sodium-induced Colitis in Mice. Digestive Diseases and Sciences, 63(11):2910-2922, 2018. Impact factor: 2.875

14. Sun H, Lee P, Yan C, Gao N, Wang JM, Fan X, Yu FS. Inhibition of Soluble Epoxide Hydrolase 2 Ameliorates Diabetic Keratopathy and Impaired Wound Healing in Mouse Corneas. Diabetes 67(8), 1162-1172, 2018. Impact factor: 8.784.

15. Zhang K, Kim H, Fu Z, Qiu Y, Yang Z, Wang JM, Zhang D, Tong X, Yin L, Li J, Wu J, Qi NR, Houten SM, Zhang R. Deficiency of the Mitochondrial NAD Kinase Causes Stress-induced hepatic steatosis in mice. Gastroenterology 154(1): 224-237, 2018. Impact factor: 18.392

16. Li H, Liu J, Wang Y, Fu Z, Huttemann M, Monks TJ, Chen AF, Wang JM*. MiR-27b augments bone marrow progenitor cell survival via suppressing the mitochondrial apoptotic pathway in type 2 diabetes. American Journal of Physiology-Endocrinology and Metabolism 313: E391-E401, 2017 Impact factor: 4.142

17. Wang JM*, Qiu YN, Yang ZQ, Li L, Zhang K*. Inositol requiring enzyme 1α facilitates diabetic wound healing through modulating microRNAs. Diabetes 66:177-192, 2017. Impact factor: 8.784.