Jiemei Wang, M.D., Ph.D.

Jiemei Wang, M.D., Ph.D.

Associate Professor

Office Location

EACPHS, Suite 3122






Pharmaceutical Sciences

Research website




Jiemei Wang, M.D., Ph.D.

Degrees and Certifications

  • 2009: Ph.D., Internal Medicine (Cardiology), Sun Yat-Sen University, Guangzhou, China
  • 2004: M.D., Clinical Medicine, Sun Yat-Sen University, Guangzhou, China
  • 2010: AHA Postdoctal fellowship, University of Pittsburgh, Pittsburgh, PA, USA

Positions and Employment

  • 2021.8 - present: Associate Professor, Department of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, MI
  • 2016.5 - 2021.8: Assistant Professor, Department of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, MI
  • 2014.7 - 2016.5: Assistant Professor - Research, Center for Molecular Medicine & Genetics Wayne State University, Detroit, MI
  • 2012 - 2014.7: Research Instructor and Research Assistant Professor, Department of Surgery, University of Pittsburgh, Pittsburgh, PA
  • 2011 - 2015: Research Associate, VA Vascular Surgery Research VA Pittsburgh Healthcare System Pittsburgh, PA


Awards and Honors

  • 2011: Distinguished Speaker, 4th Annual Translational to Clinical (T2C) Wound Care Conference. Columbia, OH.
  • 2010: The Wound Biotechnology Foundation Travel Award for Trainees, Wound Healing Society. Orlando, FL.
  • 2010: Second place in Basic Science, The American Heart Association and the Fellows Research Day, Pittsburgh, PA.
  • 2009: American Heart Association (AHA) Postdoctoral Fellowship Award, Pittsburgh, PA.
  • 2008: Scientific Sessions Merit Travel Award For Young Investigators, American Heart Association, New Orleans, LA
  • 2007: China Overseas Doctoral Scholarship Award, Guangzhou, China.
  • 2004: Physician Excellence Training Award, Sun Yat-Sen University, Guangzhou, China

Professional Memberships

  • American Heart Association
  • Wound Healing Society
  • American Society for Pharmacology and Experimental Therapeutics
  • American Diabetes Association
  • American Physiology Society
  • Rho Chi Society

Areas of Expertise

  • Diabetes
  • Cardiovascular disorders
  • Angiogenesis
  • Endothelium
  • Stress signaling

Primary Research Interest

There are two major focuses in my research:

  1. Non-coding RNA regulation of tissue regeneration. MicroRNAs are newly discovered short oligonucleotides that act as key regulators of gene expression. It is until recently that the importance of microRNA-directed gene regulation in vascular disorders has been recognized. Our project is to determine the biogenesis of miRNAs and their impact on tissue repair, in response to detrimental stress, such as diabetes, hyperlipidemia, hypertension, etc. We are working on new projects to look at some of the long non-coding RNAs (lncRNA) in regulation of anigogenesis as well.
  2. Endothelial injury and repair in disease settings. The well-being of vascular endothelium is essential to normal vascular homeostasis. Its dysfunction is one of the first steps leading to atherosclerosis. Endothelial progenitor cells (EPCs) are vascular endothelial cell (EC) precursors that are capable of differentiating into mature endothelial cells and producing new vessels but their functions are impaired in various cardiovascular diseases. We are investigating the morphogenic activities of EPCs that might contribute to EPCs’ therapeutic potentials for wound healing.

Recent Publications

1. Minjares M, Wu W, Wang JM*. Oxidative stress and microRNAs in endothelial cells under metabolic disorders. Cells 2023. Special Issue: The Role of Oxidative Stress in Cardiovascular Diseases. Under minor revision. Impact factor 7.666.

2. Mestareehi A, Li H (Co-1st), Zhang X, Meda Venkata SP, Jaiswal, Yu FS, Yi Z*, Wang JM*. Quantitative Proteomics Reveals Transforming growth factor beta Receptor targeted by Resveratrol and Hesperetin Coformulation in Endothelial Cells. ACS Omega 2023. Accepted. Impact factor 4.132

3. Wang JM*, Li H, Xu L, Kim H, Qiu Y, Zhang K*. Boosting UPR Transcriptional Activator XBP1 Accelerates Acute Wound Healing. Proceedings of the National Academy of Sciences (PNAS) Nexus 2023 Feb 14;2(3):pgad050. doi: 10.1093/pnasnexus/pgad050. Impact factor 11.205

4. Meda Venkata SP, Li H, Xu L, Koh JY, Nguyen H, Minjares M, Li C, Kowluru A, Milligan G, Wang JM*. Inhibition of GPR39 restores defects in endothelial cell-mediated neovascularization under the duress of chronic hyperglycemia: Evidence for regulatory roles of the sonic hedgehog signaling axis. Proc Natl Acad Sci U S A. 2023 Jan 3;120(1):e2208541120. doi: 10.1073/pnas.2208541120. Epub 2022 Dec 27. PubMed PMID: 36574661. Impact factor 12.78

5. Kujawa M, O'Meara M, Li H, Xu L, Meda Venkata SP, Nguyen H, Minjares M, Zhang K, Wang JM*. MicroRNA-466 and microRNA-200 increase endothelial permeability in hyperglycemia by targeting Claudin-5. Mol Ther Nucleic Acids. 2022 Sep 13;29:259-271. doi: 10.1016/j.omtn.2022.07.002. eCollection 2022 Sep 13. PubMed PMID: 35892090; PubMed Central PMCID: PMC9307898. Impact factor 8.886
Commentary: Roudier E, Lemieux P, Lam B. Treating the diabetic wound through miR inhibitor cocktails: A question of timing? Mol Ther Nucleic Acids. 2022 Dec 13; 30: 112–114.

6. Li H, Nguyen H, Meda Venkata SA, Koh JY, Kowluru A, Li L, Rossi NF, Wang JM*. A novel role of G protein-coupled receptor 35 (GPR35) in the regulation of endothelial cell function and blood pressure. Hypertension 2021;78:816-830. Impact factor 10.19

7. Nguyen H, Koh JY, Li H, Islas-Robles A, Meda Venkata SA, Wang JM*, Monks TJ*. A novel imidazolinone metformin-methylglyoxal metabolite promotes endothelial cell angiogenesis via the eNOS/HIF-1α pathway. The FASEB Journal 2021;35(7):e21645.. Impact factor 4.966.

8. Li H, O'Meara M, Zhang X, Zhang K, Seyoum B, Yi Z, Kaufman RJ, Monks T, Wang, JM*. Ameliorating Methylglyoxal-Induced Progenitor Cell Dysfunction for Tissue Repair in Diabetes. Diabetes 68(6): 1287-1302, 2019. Impact factor: 8.784

9. Wang Y, Hall LM, Kujawa M, Li H, Zhang X, Megan OM, Ichinose T, Wang JM*. Methylglyoxal Triggers Human Aortic Endothelial Cell Dysfunction via Modulating KATP/MAPK pathway. American Journal of Physiology – Cell Physiology: C68-81, 2019. Impact factor: 3.4

10. Wang JM*, Qiu Y, Zhao Y, Kim HB, Qian Q, Sun Q, Zhang C, Yin L, Fang D, Back SH, Kaufman RJ, Yin L*, Zhang K*. Inositol Requiring Enzyme 1 Prevents Hepatic Steatosis through Processing MicroRNAs. Science Signaling 11(530): eaao4617, 2018 Impact factor: 6.494.

11. Farooq SM, Hou Y, Li H, Wang Y, Li CY*, Wang JM*. Disruption of GPR35 Exacerbates Dextran Sulfate Sodium-induced Colitis in Mice. Digestive Diseases and Sciences, 63(11):2910-2922, 2018. Impact factor: 2.875

12. Sun H, Lee P, Yan C, Gao N, Wang JM, Fan X, Yu FS. Inhibition of Soluble Epoxide Hydrolase 2 Ameliorates Diabetic Keratopathy and Impaired Wound Healing in Mouse Corneas. Diabetes 67(8), 1162-1172, 2018. Impact factor: 8.784.

13. Zhang K, Kim H, Fu Z, Qiu Y, Yang Z, Wang JM, Zhang D, Tong X, Yin L, Li J, Wu J, Qi NR, Houten SM, Zhang R. Deficiency of the Mitochondrial NAD Kinase Causes Stress-induced hepatic steatosis in mice. Gastroenterology 154(1): 224-237, 2018. Impact factor: 18.392

14. Li H, Liu J, Wang Y, Fu Z, Huttemann M, Monks TJ, Chen AF, Wang JM*. MiR-27b augments bone marrow progenitor cell survival via suppressing the mitochondrial apoptotic pathway in type 2 diabetes. American Journal of Physiology-Endocrinology and Metabolism 313: E391-E401, 2017 Impact factor: 4.142

15. Wang JM*, Qiu YN, Yang ZQ, Li L, Zhang K*. Inositol requiring enzyme 1α facilitates diabetic wound healing through modulating microRNAs. Diabetes 66:177-192, 2017. Impact factor: 8.784.

16. Dandekar A, Qiu Y, Kim HB, Wang JM, Xia H, Zhang XB, Zheng Z, Roberto M, Kim HB, Yu FS, Kumar A, Fang D, Sun F, Zhang K. TLR Signaling Interacts with CREBH to Modulate HDL in Response to Bacterial Endotoxin. J Biol Chem 291:23149-23158, 2016. Impact factor: 4.258

17. Wang JM*, Chen AF, Zhang KZ. Isolation and primary culture of mouse aortic endothelial cells. J Vis Exp 118:e52965, 2016.

Courses taught by Jiemei Wang, M.D., Ph.D.

Fall Term 2023 (current)

Winter Term 2023

Fall Term 2022

Winter Term 2022

Fall Term 2021

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