Andrew Berti, Pharm.D., Ph.D.

Assistant Professor

Office Location

EACPHS, Room 4122

Phone

313-577-3565

Email

andrew.berti@wayne.edu

Department

Pharmacy Practice

Research website

https://orcid.org/0000-0001-5658-1973

Andrew Berti, Pharm.D., Ph.D.

Degrees and Certifications

2016 - Postdoctoral Fellowship, Antistaphylococcal Pharmacotherapy - University of Wisconsin-Madison
2014 - Pharm.D. - University of Wisconsin-Madison, Madison WI
2009 - Ph.D. Bacteriology - University of Wisconsin-Madison, Madison WI
2003 - B.S. Microbiology - University of Rochester, Rochester NY

Positions and Employment

2017-Present - Assistant Professor of Pharmacy Practice, Wayne State University, Eugene Applebaum College of Pharmacy and Health Sciences, Detroit, MI
2016-2017 - Infectious Diseases Research Scientist, University of Wisconsin-Madison, Madison, WI
2014-2016 - Postdoctoral Research Fellow (Dr. Warren E. Rose), University of Wisconsin-Madison
2010-2014 - Research Associate (Dr. Warren E. Rose), University of Wisconsin-Madison, Madison, WI
2009-2010 - Quality Assurance Analyst, EPIC Systems Corporation, Verona, WI
2003-2009 - Graduate Research Assistant (Dr. Michael G. Thomas), University of Wisconsin-Madison
1999-2003 - Undergraduate Research Assistant (Dr. J. Scott Butler), University of Rochester, NY

Awards and Honors

2022 - WSU College of Pharmacy Teacher of the Year
2014 - Zeeh Pharmaceutical Station Director’s Award in Science and Technology
2014 - ICAAC Infectious Disease Fellow (2014)
2014 - Borchardt Scholar
2013 - AACP Walmart Scholar

Professional Memberships

Infectious Diseases Society of America
European Society of Clinical Microbiology and Infectious Diseases
Society of Infectious Diseases Pharmacists
American Association of Colleges for Pharmacy
American Colleges of Clinical Pharmacy
American Society from Microbiology

Areas of Expertise

Antimicrobial Pharmacotherapy
Bacterial Metabolism
Secondary Metabolism/Metabolic Engineering
Molecular Biology
Recombinant Genetics
Enzymology
Pharmacokinetics/Pharmacodynamics
Mechanisms of Antimicrobial Resistance
Antimicrobial Tolerance

Primary Research Interest

The Berti Lab investigates how combining antibiotics in a deliberate and rational manner can improve outcomes for patients with challenging bacterial infections. We integrate pharmacokinetics, bacteriology, molecular biology, metabolism and recombinant genetics to examine when combination therapy is appropriate, why combination therapy can provide benefit and how best to administer antibiotic combinations.

RESEARCH OPPORTUNITIES ARE AVAILABLE FOR STUDENTS AND TRAINEES INTERESTED IN BACTERIAL METABOLISM AS WELL AS ANTI-INFECTIVES RESEARCH.

Combination Antimicrobial Therapy
Mechanisms of Antimicrobial Resistance
Mechanisms of Antimicrobial Tolerance
Optimization of Pharmacological Interventions
Staphylococcus aureus

Recent Publications

Refereed Journals

Atomwise AIMS Program. AI is a viable alternative to high through=put screening: a 318-target study. Sci Rep. 2024;14(1):7526.

Meredith EM, Harven LT, Berti AD. Antimicrobial efficacy against antibiotic-tolerant Staphylococcus aureus depends on the mechanism of antibiotic tolerance. Antibiotics. 2022;11(12):1810.

Kebriaei R, Berti AD. Editorial: Antibiotics Special issue on pharmacokinetic/pharmacodynamic models of antibiotics. Antibiotics. 2022;11(11):1540.

Gortney JS, Fava JP, Berti AD, Stewart B. Comparison of student pharmacists’ performance on in-person vs. virtual OSCEs in a pre-APPE capstone course. Curr Pharm Teach Learn. 2022. In Press.

Berti AD, Kale-Pradhan PB, Giuliano CA et al. Clinical outcomes of zinc supplementation among COVID-19 patients. Curr Drug Saf. 2022.

Lew C, Pellitteri Hahn M, Scarlett C, Rottier A, Berti AD, Proctor RA, Bayer AS, Rose WE. Proteomic correlates of enhanced daptomycin activity following β-lactam pre-conditioning in daptomycin-resistant methicillin-resistant Staphylococcus aureus. Antimicrob Agents Chemother. 2022;66(3):e0201721.

Meredith EM, Berti AD. Commentary: Synergy between beta-lactams and lipo-glyco- and lipoglycopeptides is independent of the seesaw effect in methicillin-resistant Staphylococcus aureus. Front Mol Biosci. 2021;8:774021

Miller CR, Monk JM, Szubin R, Berti AD. Rapid resistance development to three antistaphylococcal therapies in antibiotic-tolerant Staphylococcus aureus bacteremia. PLoS One. 2021;16(10):e0258592.

Berti AD, Harven LT, Bingley V. Distinct effectiveness of oritavancin against tolerance-induced Staphylococcus aureus. Antibiotics. 2020;9(11):789.

Jenson RE, Baines SL, Howden BP, Mishra NN, Farah S, Lew C, Berti AD, Shukla SK, Bayer AS, Rose WE. Prolonged exposure to β-lactam antibiotics reestablishes susceptibility of daptomycin--nonsusceptible Staphylococcus aureus to daptomycin. Antimicrob Agents Chemother. 2020;64(9):e00890-20.

Berti AD, Rose WE, Nizet V, Sakoulas G. Antibiotics and innate immunity:a cooperative effort toward the successful treatment of infectious. Submitted to Clin Infect Dis, Feb 2020.

Miller CR, Dey S, Smolenski PD, Kulkarni PS, Baines SL, Berti AD. Suppression of daptomycin resistance development in Staphylococcus aureus is a class effect of beta lactams and is independent of daptomycin-beta lactam synergy. Submitted to Antimicrob Agents Chemother, Feb 2020.

Miller CR, Dey S, Smolenski PD, Kulkarni PS, Monk JM, Szubin R, Sakoulas G. Berti AD. Distinct subpopulations of intravalvular methicillin-resistant Staphylococcus aureus with variable susceptibility to daptomycin in tricuspid valve endocarditis. Antimicrob Agents Chemother. 2020;68(1):pii: AAC.01593-19.

Berti AD, Hirsch EB. Tolerance to antibiotics affects response. Science. 2020;367(6474):141-142.

Dey S, Gudipati S, Giuliano C, Zervos MJ, Monk JM, Szubin R, Jorgensen SCJ, Sakoulas G, Berti AD. Reduced production of bacterial membrane vesicles predicts mortality in ST45/USA600 methicillin-resistant Staphylococcus aureus bacteremia. Antibiotics (Basel). 2019;9(1):pii: E2.

Ritscher AM, Ranum N, Malak JD, Ahrabi-Fard S, Baird J, Berti AD, Curtis W, Holden M, Jones CD, Kind J, Kinsey W, Koepke R, Schauer SL, Stein E, VanOrman S, Ward BG, Zahner SJ, Hayney MS. Meningococcalserogroup B outbreak response at a large public university. J Amer Coll Health. 2019;67(3):191-196.

Berti AD, Shukla N, Rottier AD, McCrone JS, Turner HM, Monk IR, Baines SL, Howden BP, Proctor RA, Rose WE (in press). Daptomycin selects for genetic and phenotypic adaptations leading to antibiotic tolerance in methicillin-resistant Staphylococcus aureus. J Antimicrob Chemother. 2018;73(8):2030-2033.

Ritscher AM, Ranum N, Malak JD, Ahrabi-Fard S, Baird J, Berti AD, Curtis W, Holden M, Jones CD, Kind J, Kinsey W, Koepke R, Schauer SL, Stein E, VanOrman S, Ward BG, Zahner SJ, Hayney MS. Meningococcal serogroup B outbreak response at a large public university. J Am Coll Health. 2018;66(3):1-6

Fernandez-Llimos F, Berti AD, Yeung D et al. Scholarly publishing depends on peer reviewers. Pharm Pract. 2018;16(1):1236.

Zheng X, Berti AD, McCrone S, Roch M, Rosato AE, Rose WE, Chen B. Combination antibiotic exposure selectively alters the development of vancomycin intermediate resistance in Staphylococcus aureus. Antimicrob Agents Chemother. 2018;62(2):e02100-17.