Guangde Jiang

Guangde Jiang

Assistant Professor

Office Location

 3136 Applebaum Building

Phone

313-577-3761

Email

guangde@wayne.edu

Department

 Pharmaceutical Sciences

Guangde Jiang

Degrees and Certifications

  • Ph.D., Medicinal Chemistry, University of Florida
  • M.S., Medicinal Chemistry, China Pharmaceutical University
  • B.S., Pharmacy, Xiangtan University, China

Postdoctoral training

  • Postdoctoral Fellow, Department of Chemical and Biomolecular Engineering, University of Illinois at Urbana-Champaign
  • Postdoctoral Research Associate, Institute for Sustainability, Energy, and Environment, University of Illinois at Urbana-Champaign

Positions and Employment

Assistant Professor, Department of Pharmaceutical Sciences, Wayne State University, 2024-Present

Awards and Honors

  • Tony and Colleen Shen Postdoctoral Fellowship, University of Illinois at Urbana-Champaign, 2021-2022
  • New Frontiers Scholar Award, Corteva Agriscience, 2019
  • Best Research Student Award, Department of Medicinal Chemistry, University of Florida, 2019
  • Poster Presentation Winner, 2019 UF Drug Discovery Symposium, 2019
  • Certificate of Excellence, University of Florida, 2018

Areas of Expertise

  • Medicinal chemistry
  • Biocatalysis
  • Synthetic biology
  • Protein engineering
  • Molecular biology
  • Natural product biosynthesis
  • Asymmetric catalysis

Primary Research Interest

  • Biocatalysis 
  • Chemoenzymatic synthesis
  • Natural product biosynthesis
  • Enzymatic cascade synthesis 

Recent Publications

19. G. Jiang, C. Huang, W. Harrison, H. Li, M. Zhou, H. Zhao*. “Ene Reductase Enabled Intramolecular βC−H Functionalization of Substituted Cyclohexanones for Efficient Synthesis of Bridged Bicyclic Nitrogen Scaffolds.” Angew. Chem., Int. Ed. 2023, DOI: 10.1002/anie.202302125. 

18. T. Yu, H. Cui, J. C. Li, Y. Luo, G. Jiang, H. Zhao*. “Enzyme Function Prediction Using Contrastive Learning.” Science. 2023, 379, 1358-1363

17. X. Huang#, J. Feng#, J. Cui#, G. Jiang#, W. Harrison, X. Zang, J. Zhou, B. Wang*, H. Zhao*. “Photoinduced Chemomimetic Biocatalysis for Enantioselective Intermolecular Radical Conjugated Addition.” Nat. Catal. 2022, 5, 586-593.  

16. D. Liu, T. N. Wanniarachchi, G. Jiang, G. M. Seabra, S. Cao, S. D. Bruner, Y. Ding*. “Biochemical and Structural Characterization of Haemophilus Influenzae Nitroreductase in Metabolizing Nitroimidazoles” RSC Chem. Biol. 2022, 3, 436-446. 

15. Y. Luo#, G. Jiang#, T. Yu, Y. Liu, L. Vo, H. Ding, Y. Su, W. W. Qian, H. Zhao*, J. Peng*. “ECNet is an Evolutionary Context-integrated Deep Learning Framework for Protein Engineering.” Nat. Commun. 2021, 12, 5743.

14. M. Chen, G. M. Rubin, G. Jiang, Y. Ding* “Biosynthesis and Heterologous Production of Mycosporine-Like Amino Acid Palythines.” J. Org. Chem. 2021, 86, 11160–11168. 

13. B. Enghiad, C. Huang, F. Guo, G. Jiang, B. Wang, S. K. Tabatabaei, T. Martin, H. Zhao*. “Cas12a Assisted Precise Targeted Cloning Using in vivo Cre-lox Recombination.” Nat. Commun. 2021, 12, 1171.

12. G. Jiang, P. Zhang, R. Ratnayake, G. Yang, Y. Zhang, R. Zuo, M. M. Powell, J. C. Huguet-Tapia, K. A. Abboud, L. H. Dang, M. Teplitski, V. Paul, R. Xiao, KH. A. U. Zaman, Z. Hu, S. Cao, H. Luesch, Y. Ding*. “Fungal Epithiodiketopiperazines Carrying α,β-polysulfide Bridges from Penicillium steckii YE, and Their Chemical Interconversion.” ChemBioChem. 2021, 22, 416-422.

11. F. Wang, A. M. Sarotti, G. Jiang, J. H. Tapia, S. Zheng, X. Wu, C. Li, Y. Ding*, S. Cao*. “Waikikiamides A-C: Complex Diketopiperazine Dimer and Diketopiperazine-polyketide Hybrids from a Hawaiian Marine Fungal Strain Aspergillus sp. FM242.” Org Lett. 2020, 22, 4408-4412.

10. X. Huang, B. Wang, Y. Wang, G. Jiang, J. Feng, H. Zhao*. “Photoenzymatic Enantioselective Intermolecular Radical Hydroalkylation.” Nature. 2020, 584, 69-74.

9. G. Jiang, Y. Zhang, M. M. Powell, S. M. Hylton, N. W. Hiller, R. Loria, Y. Ding*. “A Promiscuous Cytochrome P450 Hydroxylates Aliphatic and Aromatic C-H Bonds of Aromatic 2,5-Diketopiperazines.” ChemBioChem. 2019, 20, 1068 -1077. 

8. G. Jiang, R. Zuo, Y. Zhang, M. M. Powell, P. Zhang, S. M. Hylton, R. Loria, Y. Ding*. “One-pot Biocombinatorial Synthesis of Herbicidal Thaxtomins.” ACS Catal. 2018, 8, 10761-10768.

7. G. Jiang#, Y. Zhang#, M. M. Powell, P. Zhang, R. Zuo, D. Kallifidas, Y. Zhang, A. M. Tieu, H. Luesch, R. Loria*, Y. Ding*. “High-Yield Production of Herbicidal Thaxtomins and Analogs in a Nonpathogenic Streptomyces Host.” Appl Environ Microbiol. 2018, 84, e00164-18.

6. Y. Zhang#, G. Jiang#, Y. Ding*, R. Loria*. “Genetic Background Affects Pathogenicity Island Function and Pathogen Emergence in Streptomyces.” Mol Plant Pathol. 2018, 7, 1733-1741.

5. D. Kallifidas*, G. Jiang, Y. Ding, H. Luesch*. “Rational Engineering of Streptomyces albus J1074 for the Overexpression of Secondary Metabolite Gene Clusters.” Microb Cell Fact. 2018, 17:25.

4. M. Luo, H. Wang, Y. Zhou, S. Zhang, J. Xiao, G. Jiang, Y. Zhang, Y. Lai*. “Identification of Phenoxyacetamide Derivatives as Novel DOT1L Inhibitors via Docking Screening and Molecular Dynamics Simulation.” J Mol Graph Model. 2016, 68, 128-139. 

3. X. Feng#, G. Jiang#, Z. Xia#, J. H, X. Wang, J. Gao, Y. Lai*, Weiqing Xie*. “Total Synthesis of (-)-Conolutinine.” Org. Lett. 2015, 17, 4428-4431.

2. H. Liu#, G. Jiang#, X. Pan, X. Wan, Y. Lai*, D. Ma*, Weiqing Xie*. “Highly Asymmetric Bromocyclization of Tryptophol: Unexpected Accelerating Effect of DABCO-Derived Bromine Complex.” Org. Lett. 2014, 16, 1908-1911.

1. W. Xie*, G. Jiang, H. Liu, J. Hu, X. Pan, H. Zhang, X. Wan, Y. Lai*, D. Ma*. “Highly Enantioselective Bromocyclization of Tryptamine and Its Application on Synthesis of (-)-Chimonanthine.” Angew. Chem., Int. Ed. 2013, 52, 12924-12927. 

#: Equal contribution

 

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