Guangde Jiang
Assistant Professor
Office Location
3136 Applebaum Building
Phone
313-577-3761
Department
Pharmaceutical Sciences
Guangde Jiang
Degrees and Certifications
- Ph.D., Medicinal Chemistry, University of Florida
- M.S., Medicinal Chemistry, China Pharmaceutical University
- B.S., Pharmacy, Xiangtan University, China
Postdoctoral training
- Postdoctoral Fellow, Department of Chemical and Biomolecular Engineering, University of Illinois at Urbana-Champaign
- Postdoctoral Research Associate, Institute for Sustainability, Energy, and Environment, University of Illinois at Urbana-Champaign
Positions and Employment
Assistant Professor, Department of Pharmaceutical Sciences, Wayne State University, 2024-Present
Awards and Honors
- Tony and Colleen Shen Postdoctoral Fellowship, University of Illinois at Urbana-Champaign, 2021-2022
- New Frontiers Scholar Award, Corteva Agriscience, 2019
- Best Research Student Award, Department of Medicinal Chemistry, University of Florida, 2019
- Poster Presentation Winner, 2019 UF Drug Discovery Symposium, 2019
- Certificate of Excellence, University of Florida, 2018
Areas of Expertise
- Medicinal chemistry
- Biocatalysis
- Synthetic biology
- Protein engineering
- Molecular biology
- Natural product biosynthesis
- Asymmetric catalysis
Primary Research Interest
- Biocatalysis
- Chemoenzymatic synthesis
- Natural product biosynthesis
- Enzymatic cascade synthesis
Recent Publications
21. G. Jiang, J. Lu, M. Zhou, W. Harrison, H. Zhao*. “Multifunctional Glucose Dehydrogenase Enabled Synthesis of Chiral-Bridged Bicyclic Nitrogen Heterocycles.” ACS Catal. 2024, 14, 7074-7079.
20. W. Harrison, G. Jiang, Z, Zhang, M. Li, H. Chen, H. Zhao*. “Photoenzymatic Asymmetric Hydroamination for Chiral Alkyl Amine Synthesis.” J. Am. Chem. Soc. 2024, 146, 10716-10722.
19. G. Jiang, C. Huang, W. Harrison, H. Li, M. Zhou, H. Zhao*. “Ene Reductase Enabled Intramolecular β‐C−H Functionalization of Substituted Cyclohexanones for Efficient Synthesis of Bridged Bicyclic Nitrogen Scaffolds.” Angew. Chem., Int. Ed. 2023, DOI: 10.1002/anie.202302125.
18. T. Yu, H. Cui, J. C. Li, Y. Luo, G. Jiang, H. Zhao*. “Enzyme Function Prediction Using Contrastive Learning.” Science. 2023, 379, 1358-1363.
17. X. Huang#, J. Feng#, J. Cui#, G. Jiang#, W. Harrison, X. Zang, J. Zhou, B. Wang*, H. Zhao*. “Photoinduced Chemomimetic Biocatalysis for Enantioselective Intermolecular Radical Conjugated Addition.” Nat. Catal. 2022, 5, 586-593.
16. D. Liu, T. N. Wanniarachchi, G. Jiang, G. M. Seabra, S. Cao, S. D. Bruner, Y. Ding*. “Biochemical and Structural Characterization of Haemophilus Influenzae Nitroreductase in Metabolizing Nitroimidazoles” RSC Chem. Biol. 2022, 3, 436-446.
15. Y. Luo#, G. Jiang#, T. Yu, Y. Liu, L. Vo, H. Ding, Y. Su, W. W. Qian, H. Zhao*, J. Peng*. “ECNet is an Evolutionary Context-integrated Deep Learning Framework for Protein Engineering.” Nat. Commun. 2021, 12, 5743.
14. M. Chen, G. M. Rubin, G. Jiang, Y. Ding* “Biosynthesis and Heterologous Production of Mycosporine-Like Amino Acid Palythines.” J. Org. Chem. 2021, 86, 11160-11168.
13. B. Enghiad, C. Huang, F. Guo, G. Jiang, B. Wang, S. K. Tabatabaei, T. Martin, H. Zhao*. “Cas12a Assisted Precise Targeted Cloning Using in vivo Cre-lox Recombination.” Nat. Commun. 2021, 12, 1171.
12. G. Jiang, P. Zhang, R. Ratnayake, G. Yang, Y. Zhang, R. Zuo, M. M. Powell, J. C. Huguet-Tapia, K. A. Abboud, L. H. Dang, M. Teplitski, V. Paul, R. Xiao, KH. A. U. Zaman, Z. Hu, S. Cao, H. Luesch, Y. Ding*. “Fungal Epithiodiketopiperazines Carrying α,β-polysulfide Bridges from Penicillium steckii YE, and Their Chemical Interconversion.” ChemBioChem. 2021, 22, 416-422.
11. F. Wang, A. M. Sarotti, G. Jiang, J. H. Tapia, S. Zheng, X. Wu, C. Li, Y. Ding*, S. Cao*. “Waikikiamides A-C: Complex Diketopiperazine Dimer and Diketopiperazine-polyketide Hybrids from a Hawaiian Marine Fungal Strain Aspergillus sp. FM242.” Org Lett. 2020, 22, 4408-4412.
10. X. Huang, B. Wang, Y. Wang, G. Jiang, J. Feng, H. Zhao*. “Photoenzymatic Enantioselective Intermolecular Radical Hydroalkylation.” Nature. 2020, 584, 69-74.
9. G. Jiang, Y. Zhang, M. M. Powell, S. M. Hylton, N. W. Hiller, R. Loria, Y. Ding*. “A Promiscuous Cytochrome P450 Hydroxylates Aliphatic and Aromatic C-H Bonds of Aromatic 2,5-Diketopiperazines.” ChemBioChem. 2019, 20, 1068-1077.
8. G. Jiang, R. Zuo, Y. Zhang, M. M. Powell, P. Zhang, S. M. Hylton, R. Loria, Y. Ding*. “One-pot Biocombinatorial Synthesis of Herbicidal Thaxtomins.” ACS Catal. 2018, 8, 10761-10768.
7. G. Jiang#, Y. Zhang#, M. M. Powell, P. Zhang, R. Zuo, D. Kallifidas, Y. Zhang, A. M. Tieu, H. Luesch, R. Loria*, Y. Ding*. “High-Yield Production of Herbicidal Thaxtomins and Analogs in a Nonpathogenic Streptomyces Host.” Appl Environ Microbiol. 2018, 84, e00164-18.
6. Y. Zhang#, G. Jiang#, Y. Ding*, R. Loria*. “Genetic Background Affects Pathogenicity Island Function and Pathogen Emergence in Streptomyces.” Mol Plant Pathol. 2018, 7, 1733-1741.
5. D. Kallifidas*, G. Jiang, Y. Ding, H. Luesch*. “Rational Engineering of Streptomyces albus J1074 for the Overexpression of Secondary Metabolite Gene Clusters.” Microb Cell Fact. 2018, 17:25.
4. M. Luo, H. Wang, Y. Zhou, S. Zhang, J. Xiao, G. Jiang, Y. Zhang, Y. Lai*. “Identification of Phenoxyacetamide Derivatives as Novel DOT1L Inhibitors via Docking Screening and Molecular Dynamics Simulation.” J Mol Graph Model. 2016, 68, 128-139.
3. X. Feng#, G. Jiang#, Z. Xia#, J. H, X. Wang, J. Gao, Y. Lai*, Weiqing Xie*. “Total Synthesis of (-)-Conolutinine.” Org. Lett. 2015, 17, 4428-4431.
2. H. Liu#, G. Jiang#, X. Pan, X. Wan, Y. Lai*, D. Ma*, Weiqing Xie*. “Highly Asymmetric Bromocyclization of Tryptophol: Unexpected Accelerating Effect of DABCO-Derived Bromine Complex.” Org. Lett. 2014, 16, 1908-1911.
1. W. Xie*, G. Jiang, H. Liu, J. Hu, X. Pan, H. Zhang, X. Wan, Y. Lai*, D. Ma*. “Highly Enantioselective Bromocyclization of Tryptamine and Its Application on Synthesis of (-)-Chimonanthine.” Angew. Chem., Int. Ed. 2013, 52, 12924-12927.
#: Equal contribution